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111:352-358 (1992) Jeon GB, Lee HJ, Park JP, Park K, Choi CH, Kim SK

Notably, loss-of-function mutations in ABCG2 (e.g., Q141K) impair intestinal urate excretion, thereby significantly increasing the risk of gout ( 2.1.3 Epigenetic reprogramming Recent studies have revealed distinct DNA methylation patterns in patients with gout compared to those with hyperuricemic individuals